Scientists in Singapore say they have developed a way to track genetic changes that speeds testing of vaccines against a coronavirus that has killed more than 16 000 people worldwide.
The scientists, at the city-state’s Duke-NUS Medical School, say their technique needs just days to evaluate potential vaccines provided by Arcturus Therapeutics, an American biotech firm the school has partnered with for the trials.
The timeframe compares with the months usually required for testing based on human responses.
“You can know from the way the genes change – what genes are turned on, what are turned off,” said Ooi Eng Eong, deputy director of the school’s emerging infectious diseases programme.
Swift assessment of such changes triggered by a vaccine allows the scientists to determine its effectiveness and side effects, instead of relying solely on responses from humans who receive it, he added.
Currently, there are no approved medicines or preventive vaccines targeting the virus, with most patients receiving only supportive care, such as help with their breathing.
Experts have said getting a vaccine ready could take a year or more.
Ooi said he planned to start testing vaccines in mice in about a week, with human trials expected in the second half of the year.
Pharmaceutical firms and researchers around the globe are racing to develop vaccines and treatments for the virus, which has infected more than 377 000 people.
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